Toxic Memories in Systemic Sclerosis

Laura Duffy, Steven O'Reilly

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Systemic sclerosis is an autoimmune disease characterized by T-cell infiltration in the skin that leads to fibrosis, which can be life-limiting. Although T cells are important, it is not known which types mediate the fibrosis. The work presented by Li et al shows that memory CD8(+) cytotoxic T cells mediate fibrosis via the secretion of IL-13. IL-13 is profibrotic, and it is released in a higher amount in patients with systemic sclerosis. This suggests that targeting IL-13 may be therapeutically beneficial.

Original languageEnglish
Pages (from-to)1003-1004
Number of pages2
JournalJournal of Investigative Dermatology
Volume137
Issue number5
Early online date12 Apr 2017
DOIs
Publication statusPublished - 1 May 2017

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