Toxic Memories in Systemic Sclerosis

Laura Duffy; Steven O'Reilly

doi:10.1016/j.jid.2017.02.968

Toxic Memories in Systemic Sclerosis

Laura Duffy, Steven O'Reilly

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Systemic sclerosis is an autoimmune disease characterized by T-cell infiltration in the skin that leads to fibrosis, which can be life-limiting. Although T cells are important, it is not known which types mediate the fibrosis. The work presented by Li et al shows that memory CD8(+) cytotoxic T cells mediate fibrosis via the secretion of IL-13. IL-13 is profibrotic, and it is released in a higher amount in patients with systemic sclerosis. This suggests that targeting IL-13 may be therapeutically beneficial.

Original language	English
Pages (from-to)	1003-1004
Number of pages	2
Journal	Journal of Investigative Dermatology
Volume	137
Issue number	5
Early online date	12 Apr 2017
DOIs	https://doi.org/10.1016/j.jid.2017.02.968
Publication status	Published - 1 May 2017

Keywords

Fibrosis
Humans
Interleukin-13
Scleroderma, Systemic
Skin
Journal Article

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10.1016/j.jid.2017.02.968

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title = "Toxic Memories in Systemic Sclerosis",

abstract = "Systemic sclerosis is an autoimmune disease characterized by T-cell infiltration in the skin that leads to fibrosis, which can be life-limiting. Although T cells are important, it is not known which types mediate the fibrosis. The work presented by Li et al shows that memory CD8(+) cytotoxic T cells mediate fibrosis via the secretion of IL-13. IL-13 is profibrotic, and it is released in a higher amount in patients with systemic sclerosis. This suggests that targeting IL-13 may be therapeutically beneficial.",

keywords = "Fibrosis, Humans, Interleukin-13, Scleroderma, Systemic, Skin, Journal Article",

author = "Laura Duffy and Steven O'Reilly",

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AU - Duffy, Laura

AU - O'Reilly, Steven

PY - 2017/5/1

Y1 - 2017/5/1

N2 - Systemic sclerosis is an autoimmune disease characterized by T-cell infiltration in the skin that leads to fibrosis, which can be life-limiting. Although T cells are important, it is not known which types mediate the fibrosis. The work presented by Li et al shows that memory CD8(+) cytotoxic T cells mediate fibrosis via the secretion of IL-13. IL-13 is profibrotic, and it is released in a higher amount in patients with systemic sclerosis. This suggests that targeting IL-13 may be therapeutically beneficial.

AB - Systemic sclerosis is an autoimmune disease characterized by T-cell infiltration in the skin that leads to fibrosis, which can be life-limiting. Although T cells are important, it is not known which types mediate the fibrosis. The work presented by Li et al shows that memory CD8(+) cytotoxic T cells mediate fibrosis via the secretion of IL-13. IL-13 is profibrotic, and it is released in a higher amount in patients with systemic sclerosis. This suggests that targeting IL-13 may be therapeutically beneficial.

KW - Fibrosis

KW - Humans

KW - Interleukin-13

KW - Scleroderma, Systemic

KW - Skin

KW - Journal Article

UR - https://www.scopus.com/pages/publications/85017533512

U2 - 10.1016/j.jid.2017.02.968

DO - 10.1016/j.jid.2017.02.968

M3 - Article

C2 - 28411831

SN - 0022-202X

VL - 137

SP - 1003

EP - 1004

JO - Journal of Investigative Dermatology

JF - Journal of Investigative Dermatology

IS - 5

ER -

Toxic Memories in Systemic Sclerosis

Abstract

Keywords

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