Abstract
The scope of functionalization of 1,2,4-triazines can be considerably extended via successive nucleophilic substitution of hydrogen (S NH) and ipso-substitution. A convenient procedure has been developed for direct cyanation of 1,2,4-triazine 4-oxides with acetone cyanohydrin in the presence of triethylamine. The cyano group in the resulting 5-cyano-1,2,4-triazines is readily replaced by reactions with various aliphatic alcohols and amines.
Original language | English |
---|---|
Pages (from-to) | 744-750 |
Number of pages | 7 |
Journal | Russian Journal of Organic Chemistry |
Volume | 38 |
Issue number | 5 |
DOIs | |
Publication status | Published - May 2002 |
Externally published | Yes |