Ultrahigh sensitivity fiber biosensor for C-reactive protein detection in blood sample

Qiao Gao; Dandan Wei; Yicun Yao; Bin Liu; Juan Liu; Yingying Hu; Hong Yang; Yue Fu; Yue Zhang; Shengpeng Wan; Tao Wu; Rao Tao; Yongqing Fu; Qi Wang; Jinhui Yuan; Xing-Dao He; Qiang Wu

doi:10.1109/jsen.2025.3529694

Ultrahigh sensitivity fiber biosensor for C-reactive protein detection in blood sample

Qiao Gao, Dandan Wei, Yicun Yao, Bin Liu^*, Juan Liu, Yingying Hu, Hong Yang, Yue Fu, Yue Zhang, Shengpeng Wan, Tao Wu, Rao Tao, Yongqing Fu, Qi Wang, Jinhui Yuan^*, Xing-Dao He, Qiang Wu^*

^*Corresponding author for this work

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Abstract

Accurate and rapid detection of low concentration disease biomarkers is crucial for earlier medical diagnosis. This paper reported a tapered single mode -four core- single mode (TSFCS) structure microfiber interference biosensor for detecting low concentration of C-reactive protein (CRP). The biosensor could detect CRP solution with a concentration as low as 1 pg/mL (diluted with phosphate buffered saline), with an average wavelength shift of 0.6041 nm. The wavelength shift detected by the sensor for CRP in blood was essentially the same as the shift for an approximate concentration of CRP in PBS. This indicates that the proposed TSFCS sensor may have potential applications in the fields of biomedical diagnosis.

Original language	English
Pages (from-to)	8309-8316
Number of pages	6
Journal	IEEE Sensors Journal
Volume	25
Issue number	5
Early online date	20 Jan 2025
DOIs	https://doi.org/10.1109/jsen.2025.3529694
Publication status	Published - 1 Mar 2025

Keywords

fiber biosensor
C-reactive protein detection
microfiber
tapered fiber sensor

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title = "Ultrahigh sensitivity fiber biosensor for C-reactive protein detection in blood sample",

abstract = "Accurate and rapid detection of low concentration disease biomarkers is crucial for earlier medical diagnosis. This paper reported a tapered single mode -four core- single mode (TSFCS) structure microfiber interference biosensor for detecting low concentration of C-reactive protein (CRP). The biosensor could detect CRP solution with a concentration as low as 1 pg/mL (diluted with phosphate buffered saline), with an average wavelength shift of 0.6041 nm. The wavelength shift detected by the sensor for CRP in blood was essentially the same as the shift for an approximate concentration of CRP in PBS. This indicates that the proposed TSFCS sensor may have potential applications in the fields of biomedical diagnosis.",

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T1 - Ultrahigh sensitivity fiber biosensor for C-reactive protein detection in blood sample

AU - Gao, Qiao

AU - Wei, Dandan

AU - Yao, Yicun

AU - Liu, Bin

AU - Liu, Juan

AU - Hu, Yingying

AU - Yang, Hong

AU - Fu, Yue

AU - Zhang, Yue

AU - Wan, Shengpeng

AU - Wu, Tao

AU - Tao, Rao

AU - Fu, Yongqing

AU - Wang, Qi

AU - Yuan, Jinhui

AU - He, Xing-Dao

AU - Wu, Qiang

PY - 2025/3/1

Y1 - 2025/3/1

N2 - Accurate and rapid detection of low concentration disease biomarkers is crucial for earlier medical diagnosis. This paper reported a tapered single mode -four core- single mode (TSFCS) structure microfiber interference biosensor for detecting low concentration of C-reactive protein (CRP). The biosensor could detect CRP solution with a concentration as low as 1 pg/mL (diluted with phosphate buffered saline), with an average wavelength shift of 0.6041 nm. The wavelength shift detected by the sensor for CRP in blood was essentially the same as the shift for an approximate concentration of CRP in PBS. This indicates that the proposed TSFCS sensor may have potential applications in the fields of biomedical diagnosis.

AB - Accurate and rapid detection of low concentration disease biomarkers is crucial for earlier medical diagnosis. This paper reported a tapered single mode -four core- single mode (TSFCS) structure microfiber interference biosensor for detecting low concentration of C-reactive protein (CRP). The biosensor could detect CRP solution with a concentration as low as 1 pg/mL (diluted with phosphate buffered saline), with an average wavelength shift of 0.6041 nm. The wavelength shift detected by the sensor for CRP in blood was essentially the same as the shift for an approximate concentration of CRP in PBS. This indicates that the proposed TSFCS sensor may have potential applications in the fields of biomedical diagnosis.

KW - fiber biosensor

KW - C-reactive protein detection

KW - microfiber

KW - tapered fiber sensor

UR - https://www.scopus.com/pages/publications/85216367430

U2 - 10.1109/jsen.2025.3529694

DO - 10.1109/jsen.2025.3529694

M3 - Article

SN - 1530-437X

VL - 25

SP - 8309

EP - 8316

JO - IEEE Sensors Journal

JF - IEEE Sensors Journal

IS - 5

ER -

Ultrahigh sensitivity fiber biosensor for C-reactive protein detection in blood sample

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Keywords

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