TY - JOUR
T1 - Understanding Miro GTPases
T2 - Implications in the Treatment of Neurodegenerative Disorders
AU - Kay, Laura
AU - Pienaar, Ilse S.
AU - Cooray, Ruwini
AU - Black, Gary
AU - Soundararajan, Meera
PY - 2018/9/1
Y1 - 2018/9/1
N2 - The Miro GTPases represent an unusual subgroup of the Ras superfamily and have recently emerged as important mediators of mitochondrial dynamics and for maintaining neuronal health. It is now well-established that these enzymes act as essential components of a Ca2+-sensitive motor complex, facilitating the transport of mitochondria along microtubules in several cell types, including dopaminergic neurons. The Miros appear to be critical for both anterograde and retrograde mitochondrial transport in axons and dendrites, both of which are considered essential for neuronal health. Furthermore, the Miros may be significantly involved in the development of several serious pathological processes, including the development of neurodegenerative and psychiatric disorders. In this review, we discuss the molecular structure and known mitochondrial functions of the Miro GTPases in humans and other organisms, in the context of neurodegenerative disease. Finally, we consider the potential human Miros hold as novel therapeutic targets for the treatment of such disease.
AB - The Miro GTPases represent an unusual subgroup of the Ras superfamily and have recently emerged as important mediators of mitochondrial dynamics and for maintaining neuronal health. It is now well-established that these enzymes act as essential components of a Ca2+-sensitive motor complex, facilitating the transport of mitochondria along microtubules in several cell types, including dopaminergic neurons. The Miros appear to be critical for both anterograde and retrograde mitochondrial transport in axons and dendrites, both of which are considered essential for neuronal health. Furthermore, the Miros may be significantly involved in the development of several serious pathological processes, including the development of neurodegenerative and psychiatric disorders. In this review, we discuss the molecular structure and known mitochondrial functions of the Miro GTPases in humans and other organisms, in the context of neurodegenerative disease. Finally, we consider the potential human Miros hold as novel therapeutic targets for the treatment of such disease.
KW - Alzheimer’s disease
KW - Amyotrophic lateral sclerosis
KW - Atypical GTPase
KW - Miro GTPase
KW - Mitochondria
KW - Neurodegenerative disease
KW - Parkinson’s disease
U2 - 10.1007/s12035-018-0927-x
DO - 10.1007/s12035-018-0927-x
M3 - Review article
AN - SCOPUS:85041613871
VL - 55
SP - 7352
EP - 7365
JO - Molecular Neurobiology
JF - Molecular Neurobiology
SN - 0893-7648
IS - 9
ER -