Unveiling the Biocatalytic Aromatizing Activity of Monoamine Oxidases MAO-N and 6-HDNO: Development of Chemoenzymatic Cascades for the Synthesis of Pyrroles

Nicoló Scalacci, Gary W. Black, Giulio Mattedi, Nicola L. Brown, Nicholas J. Turner, Daniele Castagnolo

Research output: Contribution to journalArticlepeer-review

39 Citations (Scopus)
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Abstract

A chemoenzymatic cascade process for the sustainable production of pyrroles has been developed. Pyrroles were synthesized by exploiting the previously unexplored aromatizing activity of monoamine oxidase enzymes (MAO-N and 6-HDNO). MAO-N/6-HDNO whole cell biocatalysts are able to convert 3-pyrrolines into pyrroles under mild conditions and in high yields. Moreover, MAO-N can work in combination with the ruthenium Grubbs catalyst, leading to the synthesis of pyrroles from diallylamines/-anilines in a one-pot cascade metathesis–aromatization sequence.
Original languageEnglish
Pages (from-to)1295-1300
Number of pages6
JournalACS Catalysis
Volume7
Issue number2
Early online date27 Dec 2016
DOIs
Publication statusPublished - 3 Feb 2017

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