Validation of a model of regulation in the tryptophan operon against multiple experiment data using global optimisation

Jongrae Kim, Jung-Su Kim, Ian Postlethwaite, Pat Heslop-Harrison, Declan Bates

    Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

    Abstract

    This paper is concerned with validating a mathematical model of regulation in the tryptophan operon using global optimization. Although a number of models for this biochemical network are proposed, in many cases only qualitative agreement between the model output and experimental data was demonstrated, since very little information is currently available to guide the selection of parameter values for the models. This paper presents a model validating method using both multiple experimental data and global optimization.
    Original languageEnglish
    Title of host publicationProceedings of the ICCAS-SICE, 2009
    Place of PublicationPiscataway, NJ
    PublisherIEEE
    Pages209-211
    ISBN (Print)978-4907764340
    Publication statusPublished - 2009

    Publication series

    NameICROS-SICE International Joint Conference
    PublisherIEEE Xplore

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