This paper is concerned with validating a mathematical model of regulation in the tryptophan operon using global optimization. Although a number of models for this biochemical network are proposed, in many cases only qualitative agreement between the model output and experimental data was demonstrated, since very little information is currently available to guide the selection of parameter values for the models. This paper presents a model validating method using both multiple experimental data and global optimization.
|Title of host publication||Proceedings of the ICCAS-SICE, 2009|
|Place of Publication||Piscataway, NJ|
|Publication status||Published - 2009|
|Name||ICROS-SICE International Joint Conference|