Global EUV waves remain a controversial phenomenon more than 20 yr after their discovery by SOHO/EIT. Although consensus is growing in the community that they are most likely large-amplitude waves or shocks, the wide variety of observations and techniques used to identify and analyze them have led to disagreements regarding their physical properties and interpretation. Here, we use a 3D magnetohydrodynamic (MHD) model of the solar corona to simulate an EUV wave event on 2009 February 13 to enable a detailed validation of the various commonly used detection and analysis techniques of global EUV waves. The simulated event exhibits comparable behavior to that of a real EUV wave event, with similar kinematic behavior and plasma parameter evolution. The kinematics of the wave are estimated via visual identification and profile analysis, with both approaches providing comparable results. We find that projection effects can affect the derived kinematics of the wave, due to the variation in fast-mode wave speed with height in the corona. Coronal seismology techniques typically used for estimates of the coronal magnetic field are also tested and found to estimate fast-mode speeds comparable to those of the model. Plasma density and temperature variations of the wave front are also derived using a regularized inversion approach and found to be consistent with observed wave events. These results indicate that global waves are best interpreted as large-amplitude waves and that they can be used to probe the coronal medium using well-defined analysis techniques.