Xenotransplanted Human Prostate Carcinoma (DU145) Cells Develop into Carcinomas and Cribriform Carcinomas: Ultrastructural Aspects

Jacques Gilloteaux, James Jamison, Deborah Neal, Jack Summers, Henryk Taper

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Androgen-independent, human prostate carcinoma cells (DU145) develop into solid, carcinomatous xenotransplants on the diaphragm of nu/nu mice. Tumors encompass at least two poorly differentiated cell types: a rapidly dividing, eosinophilic cell comprises the main cell population and a few, but large basophilic cells able to invade the peritoneal stroma, the muscular tissue, lymph vessels. Poor cell contacts, intracytoplasmic lumina, and signet cells are noted. Lysosomal activities are reflected by entoses and programmed cell deaths forming cribriform carcinomas. In large tumors, degraded cells may align with others to facilitate formation of blood supply routes. Malignant cells would spread via ascites and through lymphatics.
Original languageEnglish
Pages (from-to)294-311
JournalUltrastructural Pathology
Volume36
Issue number5
DOIs
Publication statusPublished - 2012

Fingerprint Dive into the research topics of 'Xenotransplanted Human Prostate Carcinoma (DU145) Cells Develop into Carcinomas and Cribriform Carcinomas: Ultrastructural Aspects'. Together they form a unique fingerprint.

Cite this